منابع مشابه
Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
Chemical modification of small molecule hydrophobic drugs is a clinically proven strategy to devise prodrugs with enhanced treatment efficacy. While this prodrug strategy improves the parent drug's water solubility and pharmacokinetic profile, it typically compromises the drug's potency against cancer cells due to the retarded drug release rate and reduced cellular uptake efficiency. Here we re...
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One of the grand challenges of robotics is the design of robots that are adaptive and self-sufficient. This can be crucial for robots exposed to environments that are unstructured (in space and time) or not easily accessible for a human operator, such as the inside of a blood vessel, a collapsed building, the deep sea, or the surface of another planet.Modular reconfigurable robots are among the...
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This paper addresses the open problem of assembling multilevelled hierarchical structure. It presents a model of an infinitely-levelled, self-assembling dynamical hierarchy which arises from the interaction of geometric primary elements with a fixed complexity. A formal description of the presented hierarchy is derived. This quantifies the relative compression achieved by describing the system ...
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The three-dimensional structures of noncoding RNA molecules reveal recurring architectural motifs that have been exploited for the design of artificial RNA nanomaterials. Programmed assembly of RNA nanoobjects from autonomously folding tetraloop-receptor complexes as well as junction motifs has been achieved previously through sequence-directed hybridization of complex sets of long oligonucleot...
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ژورنال
عنوان ژورنال: Chem. Soc. Rev.
سال: 2017
ISSN: 0306-0012,1460-4744
DOI: 10.1039/c7cs00521k